What is pregnenolone? It is a steroid hormone but is not a reproductive hormone like estrogen or testosterone. Pregnenolone is also made from cholesterol, which makes it a steroid hormone. It is also considered to be a pro-hormone,’ because it can convert into other hormones depending on the needs of the body. Recently, it has been discovered that pregnenolone is also produced in the brain and spinal cord, which makes it very potent on stimulating the central nervous system and having an impact on the brain.
Pregnenolone is helpful for memory. It is stimulating to the brain for memory and learning, but at the same time, it is also neuroprotective. The brain is very complicated, and pages could be written on the process of memory foundation and degradation. What we are trying to say here is, pregnenolone helps with learning and also preserving memory by protecting brain cells.
Other helpful uses for pregnenolone:
Pregnenolone, like most hormones declines with age. However, pregnenolone can also drop in response to high levels of chronic stress. Whether that stress is mentally induced such as dealing with a family member’s illness, PTSD or a stressful high paced life. Or physical stress such as intense daily cardiovascular exercise can diminish levels of pregnenolone.
This is also known as ‘pregnenolone-steal.’ In times of chronic stress, the body will shunt the production away from the other steroid hormones to produce more cortisol. For women, the body will shunt production away from progesterone to make more cortisol.
You can test for pregnenolone levels in the blood, but the lab reference ranges are so vast that most everyone will fall in normal ranges. Quest has a reference range of 22-237 ng/dL, and LabCorp’s is anything less than 151 ng/dL.
Both are broad reference ranges. I like to see pregnenolone 80-100. If a pregnenolone blood test is less than 80 ng/ dL, I will treat the patient with pregnenolone. And after being on the pregnenolone for 1-3 months, I will retest the blood work to see where their levels are and how they are feeling.
As we all know, too much of a good thing’ is not-so-good. Taking too much pregnenolone can have side effects. There is not a lot of research on pregnenolone. There are some animal studies but not any real prolific human studies. For the layperson, there is not a lot of information about pregnenolone online. There are some contradictory statements on dosing, side effects, and safety.
What I can tell you from my experience with patients, there are relatively little side effects with pregnenolone, as long as you keep the dosage uniquely prescribed for the patient based on their symptoms and the blood work readings.
Pregnenolone is available over the counter/online without a prescription. Many pregnenolone doses are just way too high. I have had new patients walk into my office, and they are on 100mg or more of pregnenolone per day. There are a few exceptions based on blood work. But the very most I prescribe for pregnenolone is 30mg.
Like I said, too much of a good thing’ is not good. Pregnenolone is a hormone, specifically a prohormone. Meaning pregnenolone can convert into other hormones. If someone is taking a higher dose of pregnenolone, it can convert into DHEA, estradiol, cortisol, or progesterone. The side effects would occur due to the conversion of these hormones. So you might see:
These side effects come from the conversion of pregnenolone into other hormones. That is why testing for pregnenolone and patient report is essential. When used based on the patient’s blood work and symptoms, pregnenolone can really help with quality of life and aging.
Some people are not candidates for pregnenolone. As I stated before, there is not a lot of research or information on pregnenolone itself, let alone safety issues, and much of the online info regarding the safety of pregnenolone is contradictory.
Pregnenolone can convert into other hormones, so if a person has a personal or family history of a hormone receptor cancer, it is not wise to take pregnenolone. These cancers could be breast cancer or prostate cancer to name a couple.
As stated, there is not a lot of information on safety and pregnenolone; however, knowing that pregnenolone will convert to other hormones makes it potentially not a good idea for people with a personal or family history of hormone-related cancers. But we might find out otherwise in the future with more studies and research.
You are going to find that your primary care doctor is most likely not going to know what pregnenolone is, let alone test your levels. I have had primary care doctors have fits because they got pregnenolone confused with prednisone, which is of course, entirely different.
If you are interested in testing your pregnenolone, you need to see a physician that specializes in Functional Medicine. Perhaps there is not a Functional Medicine doctor in your area, or they charge more than you have budgeted for your healthcare needs. And your primary care doctor refuses to order you a pregnenolone blood test. What can you do? Order it yourself. If you are interested in pregnenolone blood testing, you can go to our website and order it yourself.
There is more to know and learn with pregnenolone. And there will be more information coming out with pregnenolone in the future as we are all learning. Hopefully, this has been informative and helpful to you. If you have any questions or personal stories about pregnenolone, please feel free to email us at [email protected]
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In this episode, we discuss the best way to reduce triglycerides. Sasha, a podcast listener, asked us how to lower her triglycerides. We then go into depth about triglycerides, how to lower them, and why they could be high in the first place.
How to read a lipid panel
Supplements for lowering triglycerides
Lifestyle changes for lowering triglycerides
What do high triglycerides mean?
Building blocks for triglycerides
Improving metabolic health
Can menopause increase triglycerides?
High triglycerides and thyroid hormones
Sacha’s Question:”I know this isn’t a hormone question but was hoping you could give me some direction. I was wondering what is the best way to lower triglycerides? thank you for your help!”
If you have a question, please visit our website and click Ask the Doctor a question.
Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns youmay have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode, we discuss a podcast listener’s question. ‘Alesha’ is concerned that she should not take estrogen replacement therapy because she has fibroids. This is a common concern. The idea that estrogen can cause or propagate fibroids has left many menopausal women without support for their symptoms. Just because women have or have had a history of fibroids does not mean they are not a candidate for estrogentherapy. In fact, women with fibroid can take estrogen hormone replacement therapy.
In this episode, we go into depth about taking estrogen with fibroids. And we break Alesha’s question into:
What are fibroids?
Fibroids and estrogen replacement therapy
Can I take estrogen if I have fibroids?
What is adenomyosis?
Estrogen’s role in fibroids
Difference between perimenopause and menopause
How menopause can affect prediabetes
Alesha’s Question:
“Is there any hope for someone with adenomyosis take estrogen? If so, when is the right time? I know adenomyosis is stimulated by estrogen. I even had 1 dr offer a hysterectomy so I could take estrogen without any issues ??!! I have a history of heavy periods have had many trans vag ultrasounds and biopsy’s over the years Uterus was enlarged, lining was wnl. Had a hysterscopy to remove some cysts they found 4 hrs ago. Last ultrasound showed probable adenomyosis.i am almost 57and I am in late perimenopause. Cycles have been erratic just went 6 months without a cycle then had a normal cycle…for years of perimenopause I had symptoms of high estrogen. Most of the time for the last year I had symptoms of low estrogen. Poor sleep waking up 4-5x night, dry skin, vaginal dryness, night sweats, brain fog, difficulty concentrating which makes my job very difficult. I have also developed mild sleep apnea(sleep lab) and after my last physical I am on the edge of pre diabetes. ( am normal weight, I walk daily and lift weights, eat high protein diet with lots of veggies and healthy fats.) I am currently taking a progesterone troche( 1/4 lozenge 50mg 2x day) and vaginal estrogen. I was taking an oral progesterone 300 mg thought it would help with sleep but didn’t. The progesterone has helped with GI issues, puffiness, bloating, cramping and anxiety.”
If you have a question, please visit our website and click Ask the Doctor a question.
Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode, we talk about POI (primary/premature ovarian insufficiency) and earlymenopause. Samantha sent in a question about whether she is in menopause or hasPOI at the age of 36.We break Samantha’s question into:- What is POI (Premature/Primary ovarian insufficiency)?- Taking estradiol during perimenopause- Difference between perimenopause and menopause- What is an FSH?- Insulin resistance and perimenopauseSamantha’s Question:I am 36 and have been slowly noticing perimenopause/low estrogen symptoms for thepast year and a half. I went to an online provider and started HRT and haveexperienced so much relief! From mental symptoms to night sweats to dryness(everywhere) I have started to feel so much better being on estradiol and progesteronefor 3 months. I have been working with a functional nutritionist on my diet, walking daily,etc.i had gestational diabetes for all 3 pregnancies and also got my tubes removed lastyear. After I came off the birth control all of my symptoms started! I recently saw mynormal OBGYN so I could get my HRT through insurance and he agreed- but made itclear this isn’t menopause, could be POI, but seemed skeptical. I got bloodwork doneand my FSH has risen in the past few months from a 3.7 to an 8. But it’s still considerednormal. All of my thyroid and other bloodwork also comes back normal. Is POI apossible diagnosis? I feel crazy!!If you have a question, please visit our website and click Ask the Doctor a question.
Disclaimer: All content in this blog, including text, images, audio, video, or other formats,was created for informational purposes only. This video, website, and blog aim topromote consumer/public understanding and general knowledge of various healthtopics. This content is not a substitute for professional medical advice, diagnosis, ortreatment. Please consult your healthcare provider with any questions or concerns youmay have regarding your condition before undertaking a new healthcare regimen.
Never disregard professional medical advice or delay seeking it because of somethingyou have read on this website. If your healthcare provider is not interested indiscussing your health concerns regarding this topic, then it is time to find a new doctor.
Can you be in both in perimenopause and menopause? Can you be menopausal andperimenopausal at the same time? The difference between perimenopause andmenopause is not a line in the sand. It is not like crossing through the Peace Arch fromBlaine Washington to the country of Canada. And at times, there is nothing peacefulabout perimenopause or menopause.There is a gray area where you are just moving out of perimenopause and intomenopause, where you are not quite in perimenopause but are not completely inmenopause. We delve deeper into the place that is between perimenopause andmenopause:- What is the difference between perimenopause and menopause?- Can you be both in perimenopause and menopause?- The difference between perimenopause and menopause- What it feels like to go from perimenopause to menopause- Can you take estrogen or biest when you are going from perimenopause tomenopause?- Is bleeding in menopause considered perimenopause?- Top symptoms of perimenopause- Top symptoms of menopause- Are you a candidate for estrogen replacement in perimenopause?If you have a question, please visit our website and click Ask the Doctor a question.Disclaimer: All content in this blog, including text, images, audio, video, or other formats,was created for informational purposes only. This video, website, and blog aim topromote consumer/public understanding and general knowledge of various healthtopics. This content is not a substitute for professional medical advice, diagnosis, ortreatment. Please consult your healthcare provider with any questions or concerns youmay have regarding your condition before undertaking a new healthcare regimen.Never disregard professional medical advice or delay seeking it because of somethingyou have read on this website. If your healthcare provider is not interested indiscussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode, we discuss a listener’s question about how to apply estriol to your face. ‘Connie’ is confused about whether she can use her Biest cream on her face. And she wanted to know the difference between estriol and Biest when it comes to treating menopausal symptoms.
We analyze Connie’s question into:
Applying estriol to the face
What is biest?
What is estriol?
What is the difference between estriol and biest?
Applying estriol vaginally
It is not a good idea to apply biest to vaginal tissues if you have a uterus
Connie’s Question:
“HI there, I loved your article on estriol for the face. I was prescribed an 80-20 bi-est cream for HRT. My question is, how is that different from a 0.3 estriol cream for the face like the kind My Alloy makes? Could I just use more of my Biest cream on my face? Would that be stronger than the My alloy 0.3 estriol cream? Lastly, the .3 estriol cream is not supposed to affect your overall hormone levels, but the Bi-est cream is supposed to affect your hormones and relieve symptoms of menopause. Why does one estriol work differently than the other? Thank you so much for any guidance you may be able to offer. It’s so hard figuring all of this out!”
If you have a question, please visit our website and click Ask the Doctor a question.
Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode we talk about where to apply hormone creams. Sadie, our listener wants to know if she needs to rotate the application sites of her hormone cream.
In this episode we discuss:
Where to apply biest cream
What to apply testosterone cream for females
Places you should not apply your testosterone cream
Best absorption sites for hormone creams
Sadie’s Question:”I have been using hormones for a little over a year. I swear by them!! I have not rotated sites at all. I use testosterone/DHEA cream behind both of my knees and E3/E2 on both of my inner thighs every morning. I take a progesterone capsule at bedtime. My doctor and everything I read says to rotate sites. I found an article by Dr. Collins and now I found your article about not having to rotate sites, so I am going to keep doing what I have been. I put the cream on both of the backs of my legs and thighs. My question is should I alternate one back of knee and then the other and the same with the inner thighs or does it matter?
If you have a question, please visit our website and click Ask the Doctor a question.
Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
