Kavinace by Neuroscience is no longer available as a supplement. April 10th, 2019, the FDA issued a letter to several nutraceutical companies to discontinue supplements containing 4-amino-3phenylbutyric acid. The FDA has determined that 4-amino-3phenylbutyric acid, also commonly referred to as Phenibut is not a dietary supplement. We published a previous Kavinace article shortly after the FDA letters were sent out.
As of the letter dated April 10th, the companies had 15 days to comply. This left people that had taken Kavinace safely for years in a bit of a quandary. Kavinace is, I mean, was a dietary supplement that many people took to help with staying asleep. It contained 950mg of a combination of taurine and 4-amino-3-phenyl butyric acid HCL per capsule.
Most people did well on one to two capsules taken at night before bed. It wasn’t a sleep medication, like Ambien or Unisom but did help to raise GABA to help with staying asleep at night. I used this myself and with patients to stay asleep at night.
Commonly in perimenopause and menopause, women have trouble staying asleep. Often they fall asleep easily but will wake up in the middle of the night for hours. And by the time they are able to fall back to sleep, it is time to wake up for the day. Kavinace was very helpful because it contained 4-amino-3-phenyl butyric acid, which is a precursor to GABA. Meaning it is easily digested and can cross the blood-brain barrier to help convert to GABA and stimulate GABA receptors to stay asleep.
One of the reasons that sleep is so important is terrible sleep can make you gain weight. People, especially women, will gain weight easily if they do not sleep well at night. Sleep is necessary for so many health reasons, it is also responsible in part for your metabolism. It really goes back to our adrenal glands.
The adrenals secrete cortisol in a diurnal fashion. Meaning that cortisol is released highest in the morning and stays up through the day and drops at night so that you can sleep well. Commonly, (especially in hormone imbalance, perimenopause, and menopause) you will see cortisol rise in the middle of the night. That causes us to wake up in the middle of the night for no reason.
Other than it is aggravating to be awake for hours in the middle of the night and tired during the day, the elevation of cortisol at night can negatively affect metabolism. Often we tell patients, forget waking up early to go to the gym. Just get that extra hour of sleep. One of the first things that we work on with patients is sleep. Sleeping properly is great for the waistline.
Well you might be asking, Kavinace is no longer available, what do I do now? There are many options available to replace Kavinace and sleep well. Back when I first found Kavinace years ago, all we had available to us was GABA. GABA is a huge molecule that is not easily absorbed through digestion, so it was a waste to take. Now we have available, PharmaGABA, which can be absorbed through the digestive tract.
PharmaGABA is a great alternative to Kavinace. You can take it as capsules at night or chewable tablets. If you are a tough sleeper, and still wake in the middle of the night, you can chew up 1-2 more tablets to help you fall back asleep and stay asleep, without feeling groggy in the morning.
Another important thing to consider when it comes to sleep is balancing the neurotransmitters. While Kavinace was a precursor to GABA, it is also important to balance dopamine and serotonin. Balancing Serotonin, Dopamine, and GABA is important for restful sleep. Often we will use products that contain 5HTP, which is a precursor to Serotonin and Mucuna pruriens standardized to 10-40% of L-Dopa which converts to dopamine.
When combining Mucuna pruriens and 5HTP with PharmaGABA can really help balance the neurohormones for healthy sleep. When people think of natural supplements for sleep, they think melatonin. Actually, melatonin can help you fall asleep, but it is not great to stay asleep.
Other ways to help with staying asleep through the night is glycine. Glycine is an amino acid that can help with feeling wound up and slow down the mind-racing. It usually comes as a powder which you mix up with water. I often like to recommend to patients to drink part of the glycine water before bed. If they wake up in the middle of the night, then finish the rest of the glycine water to fall back asleep easily without waking up groggy.
Also, phosphorylated serine is helpful for reducing cortisol levels at night to stay asleep. It doesn’t help you fall asleep, but it can help you stay asleep. Phosphorylated serine is, so it is more easily absorbed if taken with food that might have healthy fats in it.
Other options that you already know to help with sleep are no caffeine after 3pm. Also exercising, especially cardio exercise in the evening can raise your cortisol, causing trouble sleeping later that night.
Remember I talked about elevated levels of cortisol in the middle of the night causing waking? Well, that can come from low blood sugar. Let’s say you eat dinner at 6pm and nothing thereafter and go to bed at 10pm. By the time 2am comes, you have not eaten for 8 hours. Your blood sugar can drop. This causes cortisol to rise and stimulates the liver to do gluconeogenesis, which is a process to make blood sugar, even though you didn’t eat anything. This rise in cortisol from the low blood sugar makes you wake up in the middle of the night.
A good option, that I promise will not make you gain weight, is to have a bedtime snack. A small snack of protein and fat before bed is a great way to balance blood sugar to help you stay asleep at night.
We understand that you might have tried this and everything else and still have trouble staying asleep. This usually occurs in perimenopause and other hormonal imbalances. This is why we created the Perimenopause Masterclass.
If you are between the ages of your late ’30s to late ’40s and not only have trouble sleeping, but period issues, weight gain, moodiness, hair and skin issues, then this course might of interest to you.
At this point we have to say, the disclaimer …this is not meant for medical advice, please ask your doctor and if your doctor doesn’t know, get a new doctor, and this information is intended for educational purposes only, etc. But I understand that you might have more questions, please reach out anytime to [email protected]
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Are you gaining weight around your midsection during perimenopause or menopause—despite eating the same and trying everything? You’re not alone, and it’s not just about willpower: In this episode, Dr. Valorie and Dr. Maki dive deep into what’s really going on with that frustrating menopause belly. From insulin resistance to estrogen and cortisol changes, they break down the complex hormonal shifts that make weight gain in midlife feel inevitable—and nearly impossible to reverse. Here’s what we cover: ✔️ Why the “unearned weight gain” often starts in perimenopause ✔️ The truth about insulin resistance and menopausal metabolism ✔️ The role of estrogen, progesterone, and cortisol in midsection fat ✔️ Why muscle mass is your best metabolic insurance ✔️ Whether hormone replacement therapy (HRT) or GLP-1 meds (like semaglutide) can help ✔️ Actionable steps to reduce belly fat and improve metabolic health Plus, we’ll share why willpower alone doesn’t cut it—and how biology always wins unless you work with it (not against it). Want more insights like this? Be sure to subscribe to our newsletter for hormone Q&As, educational guides, and real-world strategies to help you feel like yourself again—especially during perimenopause and menopause. If you have a question, please visit our website and click Ask the Doctor a question. Join the Progress Your Health Newsletter Stay Connected Instagram: @drvalorie TikTok: @drvaloried Join the Hormone Community: Click here to subscribe Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode of the Progress Your Health Podcast, Dr. Valorie and Dr. Maki tackle a common yet surprisingly confusing question: When is the best time to test your blood levels if you’re using hormone replacement therapy (HRT)? Lisa, a fellow Washingtonian, submitted a thoughtful Ask the Doctor question about testing estradiol and FSH levels when using a trochee or transdermal cream. Should it be 4 to 6 hours after application? Or 10 to 12? And what do the results actually mean? We’ll break down: The ideal timing for blood draws depending on delivery method (trochee, patch, cream) How estrogen and progesterone absorb differently Why testing too soon — or too late — can skew your results How to interpret estradiol and FSH together (and why context is everything) Why the number isn’t the whole story — and how you feel matters most Plus, Dr. Valorie shares insights from her own hormone journey, including rhythmic dosing tips and lab timing mishaps. If you have a question, please visit our website and click Ask the Doctor a question. Want more insights like this? Be sure to subscribe to our newsletter for hormone Q&As, educational guides, and real-world strategies to help you feel like yourself again—especially during perimenopause and menopause. Join the Progress Your Health Newsletter Stay Connected Instagram: @drvalorie TikTok: @drvaloried Join the Hormone Community: Click here to subscribe Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
Is there really an age limit for hormone replacement therapy (HRT)? What if you’re in your 70s and still feel better on hormones—but your doctor says it’s time to stop? In this episode, we answer a great question from Mary, a 76-year-old woman who’s been on HRT for over 20 years. She’s dealing with weight gain, breast tenderness, and pressure from her gynecologist to quit hormones altogether. We break it down: Why stopping HRT just because of age isn’t always the answer What to consider when switching from a trochee to a cream Why estradiol levels matter more than total estrogen The connection between insulin resistance, weight gain, and hormones How to adjust HRT in your 70s to maintain quality of life without unnecessary risk Whether you’re well into postmenopause or just starting HRT, this is a must-listen if you’re wondering how long is too long to stay on hormones. If you have a question, please visit our website and click Ask the Doctor a question. Want more insights like this? Be sure to subscribe to our newsletter for hormone Q&As, educational guides, and real-world strategies to help you feel like yourself again—especially during perimenopause and menopause. Join the Progress Your Health Newsletter Stay Connected Instagram: @drvalorie TikTok: @drvaloried Join the Hormone Community: Click here to subscribe Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode, we’re answering a thoughtful (and very relatable) listener question from Kari, who’s been struggling with unexpected body pain and inflammation after starting hormone therapy. She wonders if she might be hypersensitive to estrogen—something most doctors don’t talk about. Dr. Valorie Davidson and Dr. Robert Maki unpack why this happens and what to do if you suspect your body is reacting to estrogen differently than expected. In this episode, we discuss: Why some women experience increased pain, fluid retention, or inflammation on estradiol—especially starting at higher doses too quickly. The importance of starting low and increasing slowly, especially for sensitive individuals How Dr. Davidson’s personal experience with estrogen sensitivity helped shape her approach The role of the liver’s phase 1 and phase 2 detox pathways in clearing estrogen metabolites Why form, dose, and timing of hormone therapy (cream vs. patch, AM vs. PM) can affect results What to consider when adjusting your Biest ratio (80:20 vs. 90:10) or Rhythmic Dosing HRT ✉️ Here’s Kari’s full question: “I used Biest 80:20 for 3 years and suddenly stopped absorbing. I’m not sure why, but I do know I didn’t always use it the same time every day. From the moment I went on hormone therapy I’ve had body pain and thought I had fibromyalgia. When my estrogen dropped due to the absorption issue I realized the body pain completely went away. I then went on a patch because my doc said we should change the method. Immediate body pain again and even worse. Terrible. I was on 0.025 and it was tolerable, but after raising it to 0.05 it got really bad. I think I may ask to go on the compounded cream again—maybe change the site that I apply it and be more consistent. I’m very frustrated because no one talks about a subset of people that are very sensitive to estrogen. They only talk about it making joint pain go away. Do you think I should use 90:10 instead? What would you recommend that I do? I’m so sad and frustrated.” If you have a question, please visit our website and click Ask the Doctor a question. Want more insights like this? Be sure to subscribe to our newsletter for hormone Q&As, educational guides, and real-world strategies to help you feel like yourself again—especially during perimenopause and menopause. Join the Progress Your Health Newsletter Stay Connected Instagram: @drvalorie TikTok: @drvaloried Join the Hormone Community: Click here to subscribe Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode, Dr. Valorie Davidson and Dr. Robert Maki respond to a great listener question from April, who’s navigating hormone replacement therapy (HRT) while dealing with a history of endometriosis, polyps, and chronic cramps. April’s experience is all too familiar: spotting, cramping, hormone experimentation, and the frustrating search for symptom relief. So, can women with endometriosis safely use HRT—especially estrogen? The answer: Yes, but it has to be customized. �� In this episode, we cover: Why HRT is absolutely possible for women with endometriosis—but must be individually tailored The difference between static vs. rhythmic dosing and why rhythmic HRT may be better tolerated for some women Dr. Davidson’s personal story of having endometriosis, cysts, and polyps—and how she now uses rhythmic dosing herself without flaring The important role of progesterone in managing endometriosis and minimizing estrogen reactivity How to approach spotting, cramping, and cyst formation during HRT ● Why estrogen isn’t the enemy—but why it must be dosed thoughtfully ✉️ Here’s April’s full question: “Hi—I am a 57-year-old woman in perimenopause. My question is: is it possible for women with endometriosis or adenomyosis to do HRT? I started oral progesterone 2 years ago, got as high as 300 mg, but didn’t get much symptom resolution. Switched to a progesterone troche—50 mg morning and night. About 3 months ago, I added testosterone (0.25 mg once daily, 5 days/week) and Biest 80/20 (1 ml daily, can go up to 2 ml). Everything was good for a while, but now the cramping and spotting have returned. I’ve had heavy bleeding as long as I can remember. My main complaint is menstrual cramps throughout the month—not just during my period. I do not have fibroids, but I’ve had many cysts and polyps over the years and have had many ultrasounds and transvaginal ultrasounds because of this.” If you have a question, please visit our website and click Ask the Doctor a question. Want more insights like this? Be sure to subscribe to our newsletter for hormone Q&As, educational guides, and real-world strategies to help you feel like yourself again—especially during perimenopause and menopause. Join the Progress Your Health Newsletter Stay Connected Instagram: @drvalorie TikTok: @drvaloried Join the Hormone Community: Click here to subscribe Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
In this episode, Dr. Valorie Davidson and Dr. Robert Maki dive into a hot topic: Does Hormone Replacement Therapy (HRT) actually slow down aging? While the short answer may surprise you, the real conversation is about something even more valuable—your quality of life. Here’s what we cover: How HRT can support energy, strength, and resilience as we age The role of hormones in brain function, memory, and mental clarity Why estrogen and progesterone matter for muscle tone and bone density ❤️ The powerful connection between hormones and cardiovascular health. Why HRT isn’t about extending your lifespan—but enhancing how you feel through the years Obviously aging is inevitable—but suffering doesn’t have to be. This episode is all about helping you feel more like you again, even as your hormones shift. If you have a question, please visit our website and click Ask the Doctor a question. Want more insights like this? Be sure to subscribe to our newsletter for hormone Q&As, educational guides, and real-world strategies to help you feel like yourself again—especially during perimenopause and menopause. Join the Progress Your Health Newsletter Stay Connected Instagram: @drvalorie TikTok: @drvaloried Join the Hormone Community: Click here to subscribe Disclaimer: All content in this blog, including text, images, audio, video, or other formats, was created for informational purposes only. This video, website, and blog aim to promote consumer/public understanding and general knowledge of various health topics. This content is not a substitute for professional medical advice, diagnosis, or treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition before undertaking a new healthcare regimen. Never disregard professional medical advice or delay seeking it because of something you have read on this website. If your healthcare provider is not interested in discussing your health concerns regarding this topic, then it is time to find a new doctor.
